| Intro | Sicilian-born American Mafia boss and racketeer |
| Was | Mafioso |
| From | Italy |
| Type | Crime |
| Gender | male |
| Birth | 28 March 1886, Cianciana, Province of Agrigento, Sicily, Italy |
| Death |
11 August 1954, Tampa, Hillsborough County, Florida, U.S.A. (aged 68 years) |
Santo Trafficante Sr. (May 28, 1886 – August 11, 1954) was a Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr.
Santo Trafficante Sr. gained power as a mobster in Tampa, Florida and ruled the Mafia in Tampa from the 1930s until his death in 1954. Trafficante was heavily involved in the operation of illegal bolita lotteries. During his reign, Trafficante was a well-respected boss with ties to Charles “Lucky” Luciano and Thomas Lucchese. He sent his son Santo Trafficante Jr. to New York City to learn from other mobsters. Upon his death, Santo Trafficante Sr. gave the power to his son, Santo Trafficante Jr. This was a respected decision since the New York bosses and Tampa mobsters liked Santo Jr.